1. Silibinin exhibits anti-tumor effects in a breast cancer stem cell model by targeting stemness and induction of differentiation and apoptosis

Javad Firouzi , Fattah Sotoodehnejadnematalahi, Alireza Shokouhifar , Mahsa Rahimi, Niloufar Sodeifi, Parisa Sahranavardfar, Masoumeh Azimi, Ehsan Janzamin, Majid Safa, Marzieh Ebrahimi*

BioImpacts. 2022;12(5): 415-429. doi: 10.34172/bi.2022.23336

PMCID: PMC9596878 PMID: 36381630 Scopus ID: 85140213651

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The effect of silibinin evaluated on self-renewal, tumorgenicity, and metastasis potential of Mammospheres derived from MCF-7, MDA-MB231 cell lines, and MDA-MB468 aggregated cells

Original Article

2. Growth and invasion inhibition of T47D ductal carcinoma cells by the association of docetaxel with a bioactive agent in neutral nanosuspension

Raghdah S. Bawadud , Mayson H. Alkhatib*

Bioimpacts. 2023;13(2): 145-157. doi: 10.34172/bi.2023.23515

PMCID: PMC10182446 PMID: 37193079 Scopus ID: 85152114664

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Co-delivery of NE-DTX+TQ may probably inhibit the proliferation of T47D via the induction of apoptosis and autophagy pathways and impede the migration by reducing the BCSC population and downregulating TWIST-1 expression to decrease the epithelial-to-mesenchymal transition (EMT) of breast cancer cells

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